Список последних статей лаборатории

1 Continuous Use During Disuse: Mechanisms and Effects of Spontaneous Activity of Unloaded Postural Muscle.
Shenkman BS, Kalashnikov VE, Sharlo KA, Turtikova OV, Bokov RO, Mirzoev TM.Int J Mol Sci. 2024 Nov 20;25(22):12462. doi: 10.3390/ijms252212462.PMID: 39596527 Free PMC article. Review.

2 Effects of Various Muscle Disuse States and Countermeasures on Muscle Molecular Signaling.
Sharlo K, Tyganov SA, Tomilovskaya E, Popov DV, Saveko AA, Shenkman BS.Int J Mol Sci. 2021 Dec 31;23(1):468. doi: 10.3390/ijms23010468.PMID: 35008893 Free PMC article. Review.

3 Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes.
Vilchinskaya NA, Sergeeva KV, Shenkman BS, Mirzoev TM.FEBS Open Bio. 2025 Jun;15(6):940-948. doi: 10.1002/2211-5463.70008. Epub 2025 Feb 17.PMID: 39961145 Free PMC article.

4 Six-day dry immersion leads to downregulation of slow-fiber type and mitochondria-related genes expression.
Sharlo KA, Vilchinskaya NA, Tyganov SA, Turtikova OV, Lvova ID, Sergeeva KV, Rukavishnikov IV, Shenkman BS, Tomilovskaya ES, Orlov OI.Am J Physiol Endocrinol Metab. 2023 Dec 1;325(6):E734-E743. doi: 10.1152/ajpendo.00284.2023. Epub 2023 Nov 8.PMID: 37938180 Free article.

5 SERCA activation prevents Ca2+ and ATP upregulation during 3-day soleus muscle unloading in rats.
Zaripova KA, Belova SP, Sharlo KA, Sidorenko DA, Kostrominova TY, Shenkman BS, Nemirovskaya TL.Am J Physiol Regul Integr Comp Physiol. 2025 Jul 1;329(1):R108-R122. doi: 10.1152/ajpregu.00177.2024. Epub 2025 May 28.PMID: 40433945 Free article.

6 Metformin attenuates an increase of calcium-dependent and ubiquitin-proteasome markers in unloaded muscle.
Belova SP, Zaripova K, Sharlo K, Kostrominova TY, Shenkman BS, Nemirovskaya TL.J Appl Physiol (1985). 2022 Nov 1;133(5):1149-1163. doi: 10.1152/japplphysiol.00415.2022. Epub 2022 Oct 13.PMID: 36227165 Free article.

7 AMPK Phosphorylation Impacts Apoptosis in Differentiating Myoblasts Isolated from Atrophied Rat Soleus Muscle.
Vilchinskaya NA, Rozhkov SV, Turtikova OV, Mirzoev TM, Shenkman BS.Cells. 2023 Mar 16;12(6):920. doi: 10.3390/cells12060920.PMID: 36980261 Free PMC article.

8 The Role of GSK-3β in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions.
Mirzoev TM, Sharlo KA, Shenkman BS.Int J Mol Sci. 2021 May 11;22(10):5081. doi: 10.3390/ijms22105081.PMID: 34064895 Free PMC article. Review.

9 Metformin Pre-Treatment as a Means of Mitigating Disuse-Induced Rat Soleus Muscle Wasting.
Mirzoev TM, Paramonova II, Rozhkov SV, Kalashnikova EP, Belova SP, Tyganov SA, Vilchinskaya NA, Shenkman BS.Curr Issues Mol Biol. 2023 Apr 4;45(4):3068-3086. doi: 10.3390/cimb45040201.PMID: 37185725 Free PMC article.

10 Mechanical interaction of myosin and native thin filament in the disused rat soleus muscle.
Gerzen O, Potoskueva I, Votinova V, Sergeeva K, Tyganov S, Tzybina A, Shenkman BS, Nikitina L.Life Sci Space Res (Amst). 2024 May;41:80-85. doi: 10.1016/j.lssr.2024.01.009. Epub 2024 Feb 4.PMID: 38670656

11 Molecular insights into human soleus muscle atrophy development: long-term dry immersion effects on the transcriptomic profile and posttranslational signaling.
Bokov RO, Sharlo KA, Vilchinskaya NA, Tyganov SA, Turtikova OV, Rozhkov SV, Deviatiiarov RM, Gusev OA, Tomilovskaya ES, Shenkman BS, Orlov OI.Physiol Genomics. 2025 Jun 1;57(6):357-382. doi: 10.1152/physiolgenomics.00196.2024. Epub 2025 Mar 12.PMID: 40072920 Free article.

12 Β-GPA administration activates slow oxidative muscle signaling pathways and protects soleus muscle against the increased fatigue under 7-days of rat hindlimb suspension.
Sharlo KA, Lvova ID, Sidorenko DA, Tyganov SA, Sharlo DT, Shenkman BS.Arch Biochem Biophys. 2023 Jul 15;743:109647. doi: 10.1016/j.abb.2023.109647. Epub 2023 May 24.PMID: 37230367

13 The Effect of SERCA Activation on Functional Characteristics and Signaling of Rat Soleus Muscle upon 7 Days of Unloading.
Sharlo KA, Lvova ID, Tyganov SA, Zaripova KA, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL.Biomolecules. 2023 Sep 6;13(9):1354. doi: 10.3390/biom13091354.PMID: 37759754 Free PMC article.

14 Mechanical and signaling responses of unloaded rat soleus muscle to chronically elevated β-myosin activity.
Sergeeva KV, Tyganov SA, Zaripova KA, Bokov RO, Nikitina LV, Konstantinova TS, Kalamkarov GR, Shenkman BS.Arch Biochem Biophys. 2024 Apr;754:109961. doi: 10.1016/j.abb.2024.109961. Epub 2024 Mar 14.PMID: 38492659

15 Effect of enhanced muscle tone on the expression of atrogenes and cytoskeletal proteins during postural muscle unloading.
Belova SP, Kalashnikova EP, Tyganov SA, Kostrominova TY, Shenkman BS, Nemirovskaya TL.Arch Biochem Biophys. 2022 Aug 15;725:109291. doi: 10.1016/j.abb.2022.109291. Epub 2022 May 18.PMID: 35597296

16 A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression.
Sharlo KA, Lvova ID, Tyganov SA, Sergeeva KV, Kalashnikov VY, Kalashnikova EP, Mirzoev TM, Kalamkarov GR, Shevchenko TF, Shenkman BS.Curr Issues Mol Biol. 2023 Jun 30;45(7):5613-5630. doi: 10.3390/cimb45070354.PMID: 37504270 Free PMC article.

17 Inhibition of mTORC1 differentially affects ribosome biogenesis in rat soleus muscle at the early and later stages of hindlimb unloading.
Rozhkov SV, Sharlo KA, Shenkman BS, Mirzoev TM.Arch Biochem Biophys. 2022 Nov 15;730:109411. doi: 10.1016/j.abb.2022.109411. Epub 2022 Sep 22.PMID: 36155780

18 Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.
Melnikov IY, Tyganov SA, Sharlo KA, Ulanova AD, Vikhlyantsev IM, Mirzoev TM, Shenkman BS.Pflugers Arch. 2022 Nov;474(11):1171-1183. doi: 10.1007/s00424-022-02740-5. Epub 2022 Aug 6.PMID: 35931829

19 Simulated Microgravity Changes the Number of Mechanically Gated and Mechanosensitive Ion Channels Genes Transcripts in Rat Ventricular Cardiomyocytes.
Kamkin AG, Mitrokhin VM, Kamkina OV, Kazansky VE, Rodina AS, Zolotareva AD, Zolotarev VI, Sutyagin PV, Mladenov MI, Shenkman BS, Kalashnikov VE, Orlov OI.Dokl Biochem Biophys. 2023 Oct;512(1):251-255. doi: 10.1134/S1607672923700369. Epub 2023 Dec 13.PMID: 38093125

20 P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
Zaripova KA, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL.Arch Biochem Biophys. 2024 Jan;751:109844. doi: 10.1016/j.abb.2023.109844. Epub 2023 Dec 2.PMID: 38043889

21 Changes in the Mechanical Properties of Fast and Slow Skeletal Muscle after 7 and 21 Days of Restricted Activity in Rats.
Tyganov SA, Belova SP, Turtikova OV, Vikhlyantsev IM, Nemirovskaya TL, Shenkman BS.Int J Mol Sci. 2023 Feb 18;24(4):4141. doi: 10.3390/ijms24044141.PMID: 36835551 Free PMC article.

22 Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension.
Lvova ID, Sharlo KA, Vilchinskaya NA, Sidorenko DA, Sharlo DT, Shenkman BS.Life Sci Space Res (Amst). 2023 Aug;38:8-18. doi: 10.1016/j.lssr.2023.04.003. Epub 2023 Apr 17.PMID: 37481312

23 Piezo1 activator Yoda1 promotes protein anabolism in cultured murine myotubes.
Babkova AR, Vilchinskaya NA, Sergeeva KV, Shenkman BS, Mirzoev TM.Mol Biol Rep. 2025 Oct 9;52(1):1003. doi: 10.1007/s11033-025-11115-9.PMID: 41065874

24 Cultured Myoblasts Derived from Rat Soleus Muscle Show Altered Regulation of Proliferation and Myogenesis during the Course of Mechanical Unloading.
Komarova MY, Rozhkov SV, Ivanova OA, Turtikova OV, Mirzoev TM, Dmitrieva RI, Shenkman BS, Vilchinskaya NA.Int J Mol Sci. 2022 Aug 15;23(16):9150. doi: 10.3390/ijms23169150.PMID: 36012431 Free PMC article.

25 Molecular Signaling Effects behind the Spontaneous Soleus Muscle Activity Induced by 7-Day Rat Hindlimb Suspension.
Sergeeva XV, Sharlo KA, Tyganov SA, Kalashnikov VE, Shenkman BS.Int J Mol Sci. 2024 Jul 30;25(15):8316. doi: 10.3390/ijms25158316.PMID: 39125886 Free PMC article.

26 Metformin Attenuates Slow-to-Fast Fiber Shift and Proteolysis Markers Increase in Rat Soleus after 7 Days of Rat Hindlimb Unloading.
Sharlo KA, Lvova ID, Belova SP, Zaripova KA, Shenkman BS, Nemirovskaya TL.Int J Mol Sci. 2022 Dec 28;24(1):503. doi: 10.3390/ijms24010503.PMID: 36613942 Free PMC article.

27 The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions.
Rozhkov SV, Sharlo KA, Shenkman BS, Mirzoev TM.Int J Mol Sci. 2022 Mar 2;23(5):2751. doi: 10.3390/ijms23052751.PMID: 35269893 Free PMC article.

28 Antioxidant mito-TEMPO prevents the increase in tropomyosin oxidation and mitochondrial calcium accumulation under 7-day rat hindlimb suspension.
Sidorenko DA, Galkin GV, Bokov RO, Tyrina EA, Vilchinskaya NA, Lvova ID, Tyganov SA, Shenkman BS, Sharlo KA.Free Radic Biol Med. 2024 Nov 1;224:822-830. doi: 10.1016/j.freeradbiomed.2024.10.285. Epub 2024 Oct 13.PMID: 39406275

29 Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study.
Kalashnikov VE, Tyganov SA, Turtikova OV, Kalashnikova EP, Glazova MV, Mirzoev TM, Shenkman BS.Life (Basel). 2021 Oct 30;11(11):1161. doi: 10.3390/life11111161.PMID: 34833037 Free PMC article.

30 NOS-dependent effects of plantar mechanical stimulation on mechanical characteristics and cytoskeletal proteins in rat soleus muscle during hindlimb suspension.
Tyganov SA, Mochalova EP, Melnikov IY, Vikhlyantsev IM, Ulanova AD, Sharlo KA, Mirzoev TM, Shenkman BS.FASEB J. 2021 Oct;35(10):e21905. doi: 10.1096/fj.202100783R.PMID: 34569672

31 Molecular Mechanisms of Muscle Tone Impairment under Conditions of Real and Simulated Space Flight.
Shenkman BS, Tsaturyan AK, Vikhlyantsev IM, Kozlovskaya IB, Grigoriev AI.Acta Naturae. 2021 Apr-Jun;13(2):85-97. doi: 10.32607/actanaturae.10953.PMID: 34377559 Free PMC article.

32 Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle.
Kravtsova VV, Paramonova II, Vilchinskaya NA, Tishkova MV, Matchkov VV, Shenkman BS, Krivoi II.Int J Mol Sci. 2021 Apr 10;22(8):3920. doi: 10.3390/ijms22083920.PMID: 33920198 Free PMC article.

33 Plantar Mechanical Stimulation Maintains Slow Myosin Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling.
Sharlo KA, Paramonova II, Lvova ID, Mochalova EP, Kalashnikov VE, Vilchinskaya NA, Tyganov SA, Konstantinova TS, Shevchenko TF, Kalamkarov GR, Shenkman BS.Int J Mol Sci. 2021 Jan 29;22(3):1372. doi: 10.3390/ijms22031372.PMID: 33573052 Free PMC article.

34 Role of Pannexin 1 ATP-Permeable Channels in the Regulation of Signaling Pathways during Skeletal Muscle Unloading.
Zaripova KA, Kalashnikova EP, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL.Int J Mol Sci. 2021 Sep 28;22(19):10444. doi: 10.3390/ijms221910444.PMID: 34638792 Free PMC article.

35 HDAC4 Is Indispensable for Reduced Slow Myosin Expression at the Early Stage of Hindlimb Unloading in Rat Soleus Muscle.
Paramonova II, Vilchinskaya NA, Shenkman BS.Pharmaceuticals (Basel). 2021 Nov 16;14(11):1167. doi: 10.3390/ph14111167.PMID: 34832949 Free PMC article.

36 Protective effects of low-dose lithium treatment on rat postural muscle under conditions of disuse.
Mirzoev TM, Tyganov SA, Turtikova OV, Kalashnikov VE, Sharlo KA, Shenkman BS.Pflugers Arch. 2025 Dec 5;478(1):1. doi: 10.1007/s00424-025-03138-9.PMID: 41345291 No abstract available.

37 Dynamic Foot Stimulations During Short-Term Hindlimb Unloading Prevent Dysregulation of the Neurotransmission in the Hippocampus of Rats.
Berezovskaya AS, Tyganov SA, Nikolaeva SD, Naumova AA, Merkulyeva NS, Shenkman BS, Glazova MV.Cell Mol Neurobiol. 2021 Oct;41(7):1549-1561. doi: 10.1007/s10571-020-00922-2. Epub 2020 Jul 18.PMID: 32683580 Free PMC article.

38 Ryanodine receptor stabilizer S-107 rescues slow-type rat soleus muscle function after 7-day hindlimb unloading.
Sidorenko DA, Bokov RO, Galkin GV, Vilchinskaya NA, Tyganov SA, Lvova ID, Shenkman BS, Mirzoev TM, Sharlo KA.Pflugers Arch. 2025 Oct;477(10):1245-1258. doi: 10.1007/s00424-025-03108-1. Epub 2025 Aug 5.PMID: 40762793

39 Role of PI3 Kinases in Cell Signaling and Soleus Muscle Atrophy During Three Days of Unloading.
Zaripova KA, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL.Int J Mol Sci. 2025 Jan 6;26(1):414. doi: 10.3390/ijms26010414.PMID: 39796270 Free PMC article.

40 The effect of omecamtiv mecarbil on actin-myosin interaction in the disused rat soleus muscle.
Potoskueva IK, Gerzen OP, Tzybina AE, Votinova VO, Zhigulina MV, Sergeeva KV, Tyganov SA, Shenkman BS, Nikitina LV.Arch Biochem Biophys. 2025 Jul;769:110442. doi: 10.1016/j.abb.2025.110442. Epub 2025 Apr 29.PMID: 40311993

41 Multidirectional effect of low-intensity neuromuscular electrical stimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse.
Borzykh AA, Zhedyaev RY, Ponomarev II, Vepkhvadze TF, Zgoda VG, Orlova MA, Vavilov NE, Shishkin NV, Lednev EM, Makhnovskii PA, Sharlo KA, Babkova AR, Vassilieva GY, Gimadiev RR, Shenkman BS, Rukavishnikov IV, Orlov OI, Tomilovskaya ES, Popov DV.Eur J Appl Physiol. 2025 Sep;125(9):2431-2447. doi: 10.1007/s00421-025-05761-x. Epub 2025 Apr 2.PMID: 40172600

42 Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus.
Berezovskaya AS, Tyganov SA, Nikolaeva SD, Naumova AA, Shenkman BS, Glazova MV.Life (Basel). 2021 May 17;11(5):449. doi: 10.3390/life11050449.PMID: 34067876 Free PMC article.

43 The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension.
  1. Sidorenko DA, Lvova ID, Tyganov SA, Shenkman BS, Sharlo KA.J Muscle Res Cell Motil. 2025 Sep;46(3):215-229. doi: 10.1007/s10974-025-09700-3. Epub 2025 Jul 3.PMID: 40608240
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